Publications

 

Solid Lipid Nanoparticles Loaded with Dexamethasone

🔗 DOI: 10.3390/pharmaceutics16070878

Develops dexamethasone-palmitate solid lipid nanoparticles for nebulization; demonstrates stability, efficient macrophage targeting, and reduced inflammatory cytokines.

Predicting Inhaled Drug Dose Generated by Mesh Nebulizers

🔗 DOI: 10.1089/jamp.2022.0055

Prediction formula accurately estimates inhaled drug dose via mesh nebulizer; validated using PocketAir® and comparable devices in clinical studies.

Degradation of Lipid-Based Formulations During Nebulization

🔗 DOI: 10.1016/j.chemphys.2021.111192

Discusses shear-induced damage to lipid nanoparticles during nebulization and proposes low-shear atomization enabling stable delivery of encapsulated therapeutics.

CARE: Adherence Study Among Children with Asthma

🔗 DOI: 10.1177/1753466620986391

Real-world multicentre study: 510 children using nebulized ICS. Electronic monitoring shows 69.9% adherence and improved asthma control.

Hypertonic Saline: Jet vs Portable VMN

🧾 ATS 2018

In infants with acute bronchiolitis, VMN achieved similar outcomes as jet nebulizers while earning higher caregiver satisfaction.

Polymer-Based VMN vs Metal Mesh

🧾 DDL 2018

Polymer mesh VMN shows comparable aerosol performance to metal mesh, with biocompatibility and corrosion-resistance advantages.

RCT: VMN for Infant Bronchiolitis

🔗 DOI: 10.4103/prcm.prcm_17_17

VMN matched jet nebulizer on key outcomes; families favored VMN for portability, quieter operation, and easier cleaning.

Comparing Aerosol Characteristics of VMN and Jet Nebulizers for Inhaled Antibiotics & Corticosteroids

🧾 ATS 2017

MICROVENT™ showed higher aerosol output (0.37±0.06 mL/min) and stable particle size (~4.3 μm) versus Aerogen Solo and jet nebulizers.

In Vitro Delivery Efficiency of a New T-Adaptor with Different Nebulizers During Adult Mechanical Ventilation

🧾 CTS 2017

μMVN+ with MBTC T-adaptor achieved up to 30% inhaled dose, outperforming jet nebulizer (≈12.5%) in simulated ventilation.

Vibrating-Mesh Nebulizer Particle Size & Delivery Under Ventilator Circuit Conditions

🧾 ERS 2017

MBTC μMVN maintained MMAD ≈3 μm and fine-particle fraction >75% across ventilator modes, ensuring effective pulmonary delivery.

Comparison of Aerosol Delivery Using a Specially Designed T-Adaptor with VMN in Adult Mechanical Ventilation

🧾 DDL 2017

Polymer mesh VMN with specialized T-adaptor reduced residual drug and improved fine-particle fraction compared with metal mesh designs.

Development of MicroBase Vibrating-Mesh Nebulizer Platform for Respiratory Drug Delivery

🔗 DOI: 10.6269/JRT.2017.16.2.04

Introduced MEMS-based μMVN platform with precision polymer mesh for stable droplet size and high durability in medical aerosol applications.

Aerosol Delivery Efficiency of VMN with Various T-Adaptor Designs During Mechanical Ventilation

🧾 AARC 2017

μMVN+ 2.0 with MBTC T-Adaptor achieved 30.04±0.63% inhaled dose, significantly outperforming Aerogen Solo; T-adaptor geometry impacts aerosol efficiency.

Innovative Polymer-Base Mesh (Laser-Etched)

Excimer-laser dry-etching builds polyimide meshes enabling efficient aerosol generation and superior delivery versus Omron NE-U22.

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