Develops dexamethasone-palmitate solid lipid nanoparticles for nebulization; demonstrates stability, efficient macrophage targeting, and reduced inflammatory cytokines.
Prediction formula accurately estimates inhaled drug dose via mesh nebulizer; validated using PocketAir® and comparable devices in clinical studies.
Discusses shear-induced damage to lipid nanoparticles during nebulization and proposes low-shear atomization enabling stable delivery of encapsulated therapeutics.
Real-world multicentre study: 510 children using nebulized ICS. Electronic monitoring shows 69.9% adherence and improved asthma control.
Hypertonic Saline: Jet vs Portable VMN
🧾 ATS 2018
In infants with acute bronchiolitis, VMN achieved similar outcomes as jet nebulizers while earning higher caregiver satisfaction.
Polymer-Based VMN vs Metal Mesh
🧾 DDL 2018
Polymer mesh VMN shows comparable aerosol performance to metal mesh, with biocompatibility and corrosion-resistance advantages.
VMN matched jet nebulizer on key outcomes; families favored VMN for portability, quieter operation, and easier cleaning.
Comparing Aerosol Characteristics of VMN and Jet Nebulizers for Inhaled Antibiotics & Corticosteroids
🧾 ATS 2017
MICROVENT™ showed higher aerosol output (0.37±0.06 mL/min) and stable particle size (~4.3 μm) versus Aerogen Solo and jet nebulizers.
In Vitro Delivery Efficiency of a New T-Adaptor with Different Nebulizers During Adult Mechanical Ventilation
🧾 CTS 2017
μMVN+ with MBTC T-adaptor achieved up to 30% inhaled dose, outperforming jet nebulizer (≈12.5%) in simulated ventilation.
Vibrating-Mesh Nebulizer Particle Size & Delivery Under Ventilator Circuit Conditions
🧾 ERS 2017
MBTC μMVN maintained MMAD ≈3 μm and fine-particle fraction >75% across ventilator modes, ensuring effective pulmonary delivery.
Comparison of Aerosol Delivery Using a Specially Designed T-Adaptor with VMN in Adult Mechanical Ventilation
🧾 DDL 2017
Polymer mesh VMN with specialized T-adaptor reduced residual drug and improved fine-particle fraction compared with metal mesh designs.
Introduced MEMS-based μMVN platform with precision polymer mesh for stable droplet size and high durability in medical aerosol applications.
Aerosol Delivery Efficiency of VMN with Various T-Adaptor Designs During Mechanical Ventilation
🧾 AARC 2017
μMVN+ 2.0 with MBTC T-Adaptor achieved 30.04±0.63% inhaled dose, significantly outperforming Aerogen Solo; T-adaptor geometry impacts aerosol efficiency.
Innovative Polymer-Base Mesh (Laser-Etched)
Excimer-laser dry-etching builds polyimide meshes enabling efficient aerosol generation and superior delivery versus Omron NE-U22.
Study on optimizing 248 nm excimer laser parameters for precise, low-debris microhole drilling in polyimide nozzle plates.
Developed 1-inch thermal bubble jet printhead with laser-machined PI nozzle plate, improving alignment, fabrication, and droplet performance.