Droplet Size by Laser Diffraction
Laser Diffraction Method Experiment Operation Photo

Photo of Laser Diffraction Particle Size Analyzer Experiment Operation

In the early development stages of inhalation products, laser diffraction can be utilized for droplet size testing to quickly screen for products with valuable performance. However, a drawback of this method is its inability to differentiate between multiple active pharmaceutical ingredients (APIs) in a product. Therefore, in the later stages of product development, a cascade impactor must be employed to further evaluate the aerodynamic particle size distribution (APSD).

Applicable Products
 
Nebulizers
 
Soft Mist Inhaler / SMI
 
Pressurized Metered-Dose Inhaler / pMDI
 
Nasal Sprays
 
Spray Products
Laser Diffraction Testing Principle Schematic Diagram
Testing Principle Schematic
Note: The diagram above illustrates the physical phenomenon of large-angle scattering and small-angle scattering generated when a laser beam illuminates particles. Droplet size is calculated by analyzing the scattered light energy distribution.